Properties of Guinea Pig 7s Antibodies I I . Identification of Antibodies Involved in Passive Cutaneous
نویسنده
چکیده
Passive anaphylaxis of the guinea pig has been subjected to numerous immunological studies (1). They have established for both systemic (2) and cutaneous anaphylaxis (3) the levels of specific antibody required, and the need for a latent period of sensitization (4, 5) which is generally believed to be the time required for the binding of the antibody to tissue receptors. Further evidence for antibody fixation to tissues in guinea pig anaphylaxis is derived from studies of the gamma globulins which are able to inhibit sensitization of guinea pig skin by specific antibody (6, 7) or provoke reverse passive anaphylaxis in this species (8). These effects can only be obtained with 7S gamma globulins from species, such as rabbit or man, whose antibodies can passively sensitize guinea pig skin.
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Properties of Guinea Pig 7s Antibodies I I . Identification of Antibodies Involved in Passive Cutaneous
Passive anaphylaxis of the guinea pig has been subjected to numerous immunological studies (1). They have established for both systemic (2) and cutaneous anaphylaxis (3) the levels of specific antibody required, and the need for a latent period of sensitization (4, 5) which is generally believed to be the time required for the binding of the antibody to tissue receptors. Further evidence for an...
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Guinea pig 7Sgamma(2) antibodies were demonstrated to fix complement in the presence of antigen and to sensitize antigen-coated, tanned erythrocytes for lysis in the presence of complement; guinea pig 7Sgamma(1) antibodies did not participate in these reactions. Gamma-2 antibodies were more efficient in provoking hemorrhagic necrosis in reverse passive Arthus reactions than equal amounts of non...
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High molecular weight (19S) gamma-globulin produces passive cutaneous anaphylaxis (PCA) reactions with its specific antiserum only when it is used as intravenous antigen. Reversed PCA reactions cannot be produced when the 19S protein is injected intradermally in contradistinction to the results with 7S gamma-globulin. Antibodies of the high molecular weight class, when injected intradermally, a...
متن کاملProperties of Guinea Pig 7s Antibodies I. Electrophoretic Separation of Two Types O]~ Guinea Pig
Antibodies can be considered to be molecules with two distinct sets of properties: the capacity to react specifically with antigen, and the capacity to mediate a variety of biological reactions. Some of these are: anaphylaxis, which in the guinea pig may depend upon the ability of these molecules to react with unidentified tissue receptors (1) or cell lysis (2, 3) and opsonization (4, 5) which ...
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Some properties of mouse antibodies produced by hyperimmunization with conjugated haptens, emulsified in complete adjuvant, have been investigated. Under these conditions two antigenically different types of precipitating antibody, with small differences in their electrophoretic mobilities, both migrating in the gamma-region, are produced. Both antibody types were shown to be different from the...
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